BoLCA+

Innovative botulinum polypeptide.

Cosmetics based on transdermal botulinum polypeptide:
The creation of a topical peptide derived from botulinum toxin has long been the dream of companies specialising in aesthetics. As a result, numerous projects replicating the ‘Botox effect’ have emerged. However, the products offered did not contain botulinum ingredients but were based on similar peptides such as acetyl hexapeptide-8 (argireline). With BoLCA+, Capactuel offers a genuine botulinum ingredient and high-end skin care products based on a patented ingredient, botulinum toxin polypeptide (Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40).

BoLCA+ Dermal Toxin

An innovative botulinum toxin-based solution to firm, moisturise and enhance the skin through targeted dermal injection, with multiple effects on the texture, elasticity and radiance of the face.

Dermal Toxin. Dermo Toxin.

Botulinum toxin injection

  • Face lift
  • Breast lift
  • Skin lightening
  • Skin hydration
  • Skin soothing
  • Reduces pore size
  • Sebum control
  • Facial contouring

Medical treatment
Dermal injection (100–200 times)

BoLCA+

Efficacy of Dermal Toxin+

  • Wrinkle reduction
  • Skin firming
  • Skin elasticity
  • Improvement of bruising
  • Improvement of texture
  • Removes freckles
  • Facial redness
  • Acne problems

Apply to the skin
(the more you apply, the more effective it is)

BoLCA+ DERMABOTUL INTENSIVE CARE SOLUTION

( 2ml / 0,07 fl.oz. )

A regenerating skin solution rich in active ingredients. Its innovative botulinum polypeptide (Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40) eliminates wrinkles and creases, smooths the skin, increases firmness and elasticity, and brightens and evens out the complexion. Contains sodium hyaluronate and trehalose, which increase hydration of the stratum corneum. Protects cell membranes from damage and stress factors. Can be used alone or as part of a skin care protocol.

Main ingredients

Water, Glycerin, Trehalose, Sodium Hyaluronate, Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40, sh-Oligopeptide -1 Nonapeptide-29, Sodium Chloride, Sodium Hyaluronate, Disodium Phosphate, Potassium Chloride, Potassium Phosphate, Polysorbate 20.

Sodium hyaluronate

Botulinum polypeptide

Trehalose

BoLCA+ BIOTECHNIE INTENSIVE EYE CREAM

( 25 gr / 0,88oz. )

BoLCA+ Intensive Eye Cream is a brightening cream with powerful anti-wrinkle effects designed for the eye contour area. Featuring permeability and MTD target cell penetration technology, this product contains peptides, protein ingredients and, most notably, an innovative botulinum polypeptide (Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40). Recommended for brightening the complexion, smoothing, regenerating and improving skin elasticity, the cream can be used at home or during a professional treatment.

Main ingredients

Water, Butylene Glycol, Glycerin, Methyl Gluceth-20, Cetyl Ethylhexanoate, Rosa Damascena Flower Water, Macadamia Ternifolia Seed Oil, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Niacinamide, Hydrogenated Polydecene, Centella Asiatica Extract, Morus Alba Bark Extract, Arachidyl Alcohol, Palmitoyl Penta Peptide-4, Acetyl Hexapeptide-8, Rosa Damascena Flower Extract, Behenyl Alcohol, Cetyl Alcohol, Stearyl Alcohol, Beeswax, (-)-alpha-bisabolol, Tranexamic Acid, Glycol Stearate SE, Arachidyl Glucoside, Panthenol, Dimethicone, Cetyl Alcohol, Isohexadecane, Stearic Acid, Isododecane, Carbomer, Arginine, Hydrogenated Lecithin, Tocopheryl Acetate, Allantoin, Polyacrylate-13, Sodium Hyaluronate, Beta-glucan, C13-15 Alkane, Ethylhexylbutglycerin, Polyisoene, Adenosine, Xanthan Gum, 3-O-Ethyl Ascorbic Acid, Polysorbate 20, Fragrance.

Botulinum polypeptide

MTD - EGF

MTD Hexapeptide-8

MTD Pentapeptide-4

(-)-alpha -bisabolol

Adenosine

BoLCA+ BIOTECHNIE INTENSIVE CARE MASK

( 28gr / 1.0oz. × 5 sachets. )

Reduces inflammation and promotes healing after procedures such as thread implantation, filler injections, laser treatments, or plastic surgery. The rich composition, including 15 amino acids, peptides, natural extracts and its innovative botulinum polypeptide (Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40), effectively reduces wrinkles, creases and pore size, makes the skin supple and elastic, brightens and balances the complexion. The penetration of active substances into the deeper layers of the skin ensures an occlusive effect. The cellulose-alginate-based matrix allows the mask to be applied to the face for up to 50 minutes without drying out the skin.

Main ingredients

Water, Rosa Centifolia Floral Water, Glycerin, Niacinamide, Arginine, Tranexamic Acid, Centella Asiatica and Rosa Damascena Extracts, Amino Acids (Glycine, Alanine, Leucine, etc.), Peptides (Nonapeptide-29, Pentapeptide-4), Hydrolysed Collagen, Sodium Hyaluronate, Tocopherol.

Botulinum polypeptide

MTD - EGF

MTD Hexapeptide-8

MTD Pentapeptide-4

Adenosine

Alginic acid

BoLCA+ ingredient and other botulinum ingredients

Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40

Toxin complex
(Medical injection of Botox)

Composition

Heavy chain:
Penetration of nerve cells

Light chain:
Active part of botulinum
Haemagglutinin Non-toxin Non-haemagglutinin

Marketed since 1980

Example

BOTOX (Allergan) MEDITOXIN (Meditox)
Not authorised for use in cosmetics

Molecular weight 900KDa

Pure toxin
(Medical injection of Botox)

Composition

Heavy chain:
Penetration of nerve cells

Light chain:
Effective part of Botulinum

Marketed since 1995

Example

XEOMIN (Merz)
Not authorised for use in cosmetics

Molecular weight 150KDa

BoLCA Ingredient

Composition

Light chain:
Active part of botulinum toxin

MTD:
Macromolecule transmission domain
(Penetration of skin and nerve cells)

Marketed since 2014

First botulinum ingredient on ICID

Molecular weight 50KDa

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