Discover the power of recombinant enzymes
PBSERUM has developed a unique two-generation technology using recombinant DNA to create bacterial-origin enzymes that mimic human enzymes.
Key highlights of pbserum enzymes include:
- Efficacy and Safety: high substrate specificity and selectivity ensure effective treatment for a range of skin conditions, including wrinkles, scars, lack of firmness and uneven texture. Their role in tissue regeneration helps improve skin health and appearance.
- Purity and Stability: achieved through a freeze-drying (lyophilization) process that dehydrates active ingredients by rapid freezing and sublimation under reduced pressure. This method maintains 100% enzyme activity and properties, ensuring product stability without the need for preservatives or additives.
- Low Immunogenicity: recombinant technology ensures these enzymes have a low level of immunogenicity, making treatments safe and minimizing adverse immune responses.
These characteristics have enabled the development of safe and efficacious products for a range of treatments. By using pbserum's recombinant enzymes products, healthcare providers can offer advanced, safe, and effective treatments for various skin conditions, enhancing overall patient outcomes through innovative biotechnological solutions.
Active ingredients
Experience shows a synergistic action of the enzyme cocktail compared with the potency of each enzyme on its own. Each enzyme targets a specific substrate of the skin matrix: collagenases G/H act on altered collagen fibres, hyaluronidase on hyaluronic acid, and lyase helps to fluidify the extracellular matrix, facilitating the action of the other enzymes; lipase and keratinase complete the cocktail's spectrum of action. This combined action promotes matrix renewal and stimulates fibroblasts, with the formation of new collagen and elastin fibres, for firmer, smoother, better-quality skin.
Hyaluronidase PB3000 - Collagenase G/H PB220 - Lipase PB500 - Lyase PB72K - Kératinase PB333
What are enzymes?
Enzymes are proteins that act as biological catalysts, speeding up essential chemical reactions without being consumed.
Recombinant enzymes are engineered using recombinant DNA technology, allowing for large-scale production with consistent quality.
pbserum's recombinant enzymes, developed through cutting-edge biotechnological research in Albacete, Spain, use a unique biotechnology to optimise regenerative skin treatments and open up new perspectives in aesthetic medicine.
What distinguishes pbserum?
Unique Recombinant Technology: Our enzymes are produced using a proprietary recombinant technology that ensures high purity, consistency, and efficacy.
Bacterial Origin: They are derived from bacterial sources, mimicking human enzymes for enhanced compatibility and effectiveness.
Strict Quality Standards: We operate under the most stringent health and manufacturing protocols, ensuring superior safety and reliability.
Global Validation: Our enzymes are recognized as a global standard, with extensive validation from thousands of patients and specialists across more than 50 countries. These factors combine to make pbserum’s enzymes a leading choice in the field.
Reveal
Refine
Indications:
Contour
Rebalance
Indications:
Submental area, body contour, surface irregularities.
Revive
Indications:
Skin retractions, visible marks on the skin.
Advantages and mechanism behind recombinant enzymes
Recombinant enzymes promote remodeling and regeneration of the tissues, improving theirquality without causing cell damage, which differentiates them from otherprocedures available on the market.
Substrate Specificity
Recombinant enzymes exhibit high specificity for their substrates, ensuring targeted catalytic activity. This reduces adverse effects, enhancing their safety.
Safety
Recombinant enzymes offer high purity and consistency, minimizing risks of contamination and immunogenic responses.
Efficacy
Hyal Balance
Hyal Precision Balance
Characteristics:
Enzymatic formula based on recombinant hyaluronidase, with high substrate specificity. For healthcare professionals only.
Hyal Total Balance
Characteristics:
Complete version of the Hyal Balance range, based on recombinant hyaluronidase. For healthcare professionals only.
Active ingredients
Hyaluronidase PB3000
Smarkter
Professional Hyaluronic
Target patient:
Patients with dry, dehydrated skin and visible expression lines.
Active ingredients
Keratinase PB333, Hyaluronic Acid (HMW and LMW).
Daily
Anti-Wrinkle
Target patient:
Loss of hydration
Active ingredients
Keratinase PB333, Alpinia Galanga Extract, Carnosine and Hyaluronic Acid (LMW).
Specific Periocular
Benefits:
Helps improve the appearance of the eye contour, providing a more rested and luminous appearance.
Box containing 3 vials of lyophilized powder and 3 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, vitamins C and E, ferulic acid, tranexamic acid, and troxerutin
Box with 1 eye contour serum
(12 mL)
Enzyme system:
Keratinase PB333
Active ingredients:
Hyaluronic Acid (LMW*), Vitamin C and Kojic Acid
Specific Acne Scars
Benefits:
Helps improve the appearance of facial skin with uneven texture and visible marks, promoting a more uniform and refined appearance.
Box containing 4 vials of lyophilized powder and 4 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, zinc sulfate, vitaminA, vitamin B3, niacinamide, and melatonin.
Box with 1 facial serum (30 mL)
Enzyme system:
Keratinase PB333 and collagenases G and H PB220
Active ingredients:
Hyaluronic acid (LMW*), vitamin C and DMAE
Specific Hands
Benefits:
Helps improve the appearance of the skin on the hands, contributing to a more even tone and a smoother texture.
Box containing 3 vials of lyophilized powder and 3 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, vitamins C and E, ferulic acid, tranexamic acid and DMAE
Box with 1 hand serum (30
mL)
Enzyme system:
Keratinase PB333
Active ingredients:
Hyaluronic acid (LMW*), vitamin C and DMAE
Results
Orange-peel appearance
Author: Dra. Mariana Martha Cruz Roncal (México)
Post surgical fibrosis
Author: Dra. Loira Ronquillo (Ecuador)
Scars
Author: Dra. Maira González (Venezuela)
Skin quality – face
Author: Dr. Eduardo Ortega (Perú)
Lower-face firmness
Author: Dr. Claudio A. Freixes (México)
Skin firmness – body
Author: Dra. Marcela Alpirez (Guatemala)
Patient satisfaction up to 95%(1)
Recombinant enzyme treatment in aesthetic medicine yielded highly favorable results, with patient satisfaction ranging from 86.9% to 94.7% across various aesthetic indications.
0% of severe adverse effects reported(1)
No serious adverse effects or complications were reported with the use of pbserum recombinant enzymes in over 200 patients from the clinical experience.
Significant improvements in various parameters of scar fibrosis(2)
Improvement in vascularity by up to 85%, reduction in rigidity by up to 55%, and reduction in pruritus by up to 68%.