BoLCA+
Innovative botulinum polypeptide.
Cosmetics based on topically applied botulinum polypeptide:
The creation of a topical peptide derived from botulinum toxin has long been the dream of companies specialising in aesthetics. As a result, numerous projects replicating the ‘Botox effect’ have emerged. However, the products offered did not contain botulinum ingredients but were based on similar peptides such as acetyl hexapeptide-8 (argireline). With BoLCA+, Capactuel offers a genuine botulinum ingredient and high-end skin care products based on a patented ingredient, botulinum toxin polypeptide (ATGC-BoLC).
BoLCA+ DERMABOTUL INTENSIVE CARE SOLUTION

( 2ml / 0,07 fl.oz. )
A regenerating skin solution rich in active ingredients. Its innovative botulinum polypeptide (ATGC-BoLC) eliminates wrinkles and creases, smooths the skin, increases firmness and elasticity, and brightens and evens out the complexion. Contains sodium hyaluronate and trehalose, which increase hydration of the stratum corneum. Protects cell membranes from damage and stress factors. Can be used alone or as part of a skin care protocol.
Main ingredients
Water, Glycerin, Trehalose, Sodium Hyaluronate, ATGC-BoLC, sh-Oligopeptide -1 Nonapeptide-29, Sodium Chloride, Sodium Hyaluronate, Disodium Phosphate, Potassium Chloride, Potassium Phosphate, Polysorbate 20.

Sodium hyaluronate

Botulinum polypeptide

Trehalose
BoLCA+ BIOTECHNIE INTENSIVE EYE CREAM

( 25 gr / 0,88oz. )
BoLCA+ Intensive Eye Cream is a brightening cream with powerful anti-wrinkle effects designed for the eye contour area. Featuring MTD skin absorption technology, this product contains peptides, protein ingredients and, most notably, an innovative botulinum polypeptide (ATGC-BoLC). Recommended for brightening the complexion, smoothing, regenerating and improving skin elasticity, the cream can be used at home or during a professional treatment.
Main ingredients
Water, Butylene Glycol, Glycerin, Methyl Gluceth-20, Cetyl Ethylhexanoate, Rosa Damascena Flower Water, Macadamia Ternifolia Seed Oil, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Niacinamide, Hydrogenated Polydecene, Centella Asiatica Extract, Morus Alba Bark Extract, Arachidyl Alcohol, Palmitoyl Penta Peptide-4, Acetyl Hexapeptide-8, Rosa Damascena Flower Extract, Behenyl Alcohol, Cetyl Alcohol, Stearyl Alcohol, Beeswax, (-)-alpha-bisabolol, Tranexamic Acid, Glycol Stearate SE, Arachidyl Glucoside, Panthenol, Dimethicone, Cetyl Alcohol, Isohexadecane, Stearic Acid, Isododecane, Carbomer, Arginine, Hydrogenated Lecithin, Tocopheryl Acetate, Allantoin, Polyacrylate-13, Sodium Hyaluronate, Beta-glucan, C13-15 Alkane, Ethylhexylbutglycerin, Polyisoene, Adenosine, Xanthan Gum, 3-O-Ethyl Ascorbic Acid, Polysorbate 20, Fragrance.

Botulinum polypeptide

MTD - EGF

MTD Hexapeptide-8

MTD Pentapeptide-4

(-)-alpha -bisabolol

Adenosine
BoLCA+ BIOTECHNIE INTENSIVE CARE MASK

( 28gr / 1.0oz. × 5 sachets. )
Reduces inflammation and promotes healing after aesthetic procedures such as laser treatments or plastic surgery. The rich composition, including 15 amino acids, peptides, natural extracts and its innovative botulinum polypeptide (ATGC-BoLC), effectively reduces wrinkles, creases and pore size, makes the skin supple and elastic, brightens and balances the complexion. The occlusive effect of the mask optimises the absorption of active ingredients and prolongs hydration. The cellulose-alginate-based matrix allows the mask to be applied to the face for up to 50 minutes without drying out the skin.
Main ingredients
Water, Rosa Centifolia Floral Water, Glycerin, Niacinamide, Arginine, Tranexamic Acid, Centella Asiatica and Rosa Damascena Extracts, Amino Acids (Glycine, Alanine, Leucine, etc.), Peptides (Nonapeptide-29, Pentapeptide-4), Hydrolysed Collagen, Sodium Hyaluronate, Tocopherol.

Botulinum polypeptide

MTD - EGF

MTD Hexapeptide-8

MTD Pentapeptide-4

Adenosine

Alginic acid
BoLCA+ ingredient and other botulinum ingredients
ATGC-BoLC
Toxin complex
(medical use)
Composition
Heavy chain:
Skin absorption
Light chain:
Active part of botulinum
Haemagglutinin Non-toxin Non-haemagglutinin
Marketed since 1980
Example
BOTOX (Allergan) MEDITOXIN (Meditox)
Not authorised for use in cosmetics
Molecular weight 900KDa
Pure toxin
(medical use)
Composition
Heavy chain:
Skin absorption
Light chain:
Effective part of Botulinum
Marketed since 1995
Example
XEOMIN (Merz)
Not authorised for use in cosmetics
Molecular weight 150KDa
BoLCA Ingredient
Composition
Light chain:
Active part of botulinum toxin
MTD:
Macromolecule transmission domain
(Skin absorption)
Marketed since 2014
First botulinum ingredient on ICID
Molecular weight 50KDa

