Discover the power of recombinant enzymes
PBSERUM has developed a unique two-generation technology using recombinant DNA to create bacterial-origin enzymes that mimic human enzymes.
Key highlights of pbserum enzymes include:
- Efficacy and Safety: high substrate specificity and selectivity ensure effective treatment for a range of skin conditions, including wrinkles, scars, cellulite, and localized fat. Their role in tissue regeneration helps improve skin health and appearance.
- Purity and Stability: achieved through a freeze-drying (lyophilization) process that dehydrates active ingredients by rapid freezing and sublimation under reduced pressure. This method maintains 100% enzyme activity and properties, ensuring product stability without the need for preservatives or additives.
- Low Immunogenicity: recombinant technology ensures these enzymes have a low level of immunogenicity, making treatments safe and minimizing adverse immune responses.
These characteristics have enabled the development of safe and efficacious products for a range of treatments. By using pbserum's recombinant enzymes products, healthcare providers can offer advanced, safe, and effective treatments for various skin conditions, enhancing overall patient outcomes through innovative biotechnological solutions.
Active ingredients
Experience shows a synergistic action of the enzyme cocktail compared to the potency of each enzyme separately. Almost all pathologies treated with the pbserum product line include a component of fibrosis with atrophy or hypertrophy due to alteration of collagen structure (substrate of collagenases G/H) and accumulated adipose tissue (substrate of lipase), while lyase reduces local edema and ECM viscosity, facilitating the diffusion of the remaining enzymes. The joint action promotes tissue remodeling, since the degradation of specific substrates promotes chemotaxis and fibroblast action, with formation of new collagen and elastin fibers.
Hyaluronidase PB3000 - Collagenase G/H PB220 - Lipase PB500 - Lyase PB72K - Kératinase PB333
What are enzymes?
Enzymes are proteins that act as biological catalysts, speeding up essential chemical reactions without being consumed.
Recombinant enzymes are engineered using recombinant DNA technology, allowing for large-scale production with consistent quality.
pbserum's recombinant enzymes, developed through advanced biotechnological research in Albacete, Spain, utilize unique biotechnology to enhance regenerative treatments for various pathologies and skin disorders, revolutionizing global medicine and expanding therapeutic possibilities.
What distinguishes pbserum?
Unique Recombinant Technology: Our enzymes are produced using a proprietary recombinant technology that ensures high purity, consistency, and efficacy.
Bacterial Origin: They are derived from bacterial sources, mimicking human enzymes for enhanced compatibility and effectiveness.
Strict Quality Standards: We operate under the most stringent health and manufacturing protocols, ensuring superior safety and reliability.
Global Validation: Our enzymes are recognized as a global standard, with extensive validation from thousands of patients and specialists across more than 50 countries. These factors combine to make pbserum’s enzymes a leading choice in the field.
Reveal
Advantages of recombinant enzymes
Substrate Specificity
Recombinant enzymes exhibit high specificity for their substrates, ensuring targeted catalytic activity. This reduces adverse effects, enhancing their safety.
Safety
Recombinant enzymes offer high purity and consistency, minimizing risks of contamination and immunogenic responses.
Efficacy
MECHANISM OF ACTION OF RECOMBINANT ENZYMES
Recombinant enzymes promote remodeling and regeneration of the tissues, improving theirquality without causing cell damage, which differentiates them from otherprocedures available on the market.
Refine
Indications:
Contour
Rebalance
Indications:
Submental area, body contour, surface irregularities.
Revive
Indications:
Skin retractions, visible marks on the skin.
HA Corrector
HA Partial Corrector
Benefits:
Designed for the management of mild complications arising from hyaluronic acid fillers, such as the Tyndall effect (bluish skin coloration), temporary nodules or lumps, temporary asymmetry, excess volume, undesired final result.
HA Total Corrector
Benefits:
Designed for severe complications arising from hyaluronic acid fillers, such as skin necrosis, vascular occlusion, “starting from scratch”.
Active ingredients
Hyaluronidase PB3000
Smarkter
Professional Hyaluronic
Target patient:
Patients with dry, dehydrated skin and visible expression lines.
Active ingredients
Keratinase PB333, Hyaluronic Acid (HMW and LMW).
Daily
Anti-Wrinkle
Target patient:
Loss of hydration
Active ingredients
Keratinase PB333, Alpinia Galanga Extract, Carnosine and Hyaluronic Acid (LMW).
Specific Periocular
Benefits:
Helps improve the appearance of the eye contour, providing a more rested and luminous appearance.
Box containing 3 vials of lyophilized powder and 3 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, vitamins C and E, ferulic acid, tranexamic acid, and troxerutin
Box with 1 eye contour serum
(12 mL)
Enzyme system:
Keratinase PB333
Active ingredients:
Hyaluronic Acid (LMW*), Vitamin C and Kojic Acid
Specific Acne Scars
Benefits:
Hhelps improve the appearance of facial skin with uneven texture and visible marks, promoting a more uniform and refined appearance.
Box containing 4 vials of lyophilized powder and 4 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, zinc sulfate, vitaminA, vitamin B3, niacinamide, and melatonin.
Box with 1 facial serum (30 mL)
Enzyme system:
Keratinase PB333 and collagenases G and H PB220
Active ingredients:
Hyaluronic acid (LMW*), vitamin C and DMAE
Specific Hands
Benefits:
Helps improve the appearance of the skin on the hands, contributing to a more even tone and a smoother texture.
Box containing 3 vials of lyophilized powder and 3 vials of reconstitution solution
Enzyme system:
Collagenases G and H PB220 and Lyase PB72K
Active ingredients:
Allantoin, vitamins C and E, ferulic acid, tranexamic acid and DMAE
Box with 1 hand serum (30
mL)
Enzyme system:
Keratinase PB333
Active ingredients:
Hyaluronic acid (LMW*), vitamin C and DMAE
Results
Cellulite
Author: Dra. Mariana Martha Cruz Roncal (México)
Post surgical fibrosis
Author: Dra. Loira Ronquillo (Ecuador)
Scars
Author: Dra. Maira González (Venezuela)
Face reshaping
Author: Dr. Eduardo Ortega (Perú)
Double chin
Author: Dr. Claudio A. Freixes (México)
Localized fat
Author: Dra. Marcela Alpirez (Guatemala)
Patient satisfaction up to 95%(1)
Recombinant enzyme treatment in aesthetic medicine yielded highly favorable results, with patient satisfaction ranging from 86.9% to 94.7% across various indications such as double chin, jowl, and localized fat.
0% of severe adverse effects reported(1)
No serious adverse effects or complications were reported with the use of pbserum recombinant enzymes in over 200 patients from the clinical experience.
Significant improvements in various parameters of scar fibrosis(2)
Improvement in vascularity by up to 85%, reduction in rigidity by up to 55%, and reduction in pruritus by up to 68%.